Passive stiffness of the heart is determined largely by extracellular matrix and titin. which functions as a molecular spring within sarcomeres. Titin stiffening is associated with the development of diastolic dysfunction (DD). while augmented titin compliance appears to impair systolic performance in dilated cardiomyopathy. https://www.allfixelectricales.shop/product-category/dishwasher-door-seal/
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